Award details

The structural and functional characterisation of the ERp57/ER lectin complexes of the endoplasmic reticulum

Reference	B11882
Principal Investigator / Supervisor	Professor Stephen High
Co-Investigators / Co-Supervisors
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	165,900
Status	Completed
Type	Research Grant
Start date	13/12/1999
End date	13/12/2002
Duration	36 months

Abstract

In order to facilitate protein folding, the lumen of the ER contains a complex array of molecular chaperones. However, relatively little is known about how these ER chaperones function. We have shown that when glycoproteins are made at the ER, it is molecular chaperone complexes that modulate their folding. These complexes consist of ERp57 bound to one of the ER lectins, calnexin or calreticulum. The aim of this project is to characterise the structure of these novel ERp57ER lectin complexes, and elucidate the functional consequences of them acting as a complex rather than individual components. Incorrect protein folding at the ER has serious implications for human health and can result in diseases such as Alzheimer's , BSE and cystic fibrosis. Hence this study will have wide ranging implications for both the pharmaceutical and biotechnology industries.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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