Award details

The structure of a potassium channel (KcsA) in its membrane environment

Reference	B11862
Principal Investigator / Supervisor	Professor Anthony Lee
Co-Investigators / Co-Supervisors	Professor J East
Institution	University of Southampton
Department	Centre for Biological Sciences
Funding type	Research
Value (£)	159,085
Status	Completed
Type	Research Grant
Start date	01/09/1999
End date	01/09/2002
Duration	36 months

Abstract

The aims are to (i) to use fluorescence energy transfer measurements to define the structure of the K+ channel (KcsA) from Streptomyces lividans in its membrane environment, especially the structures of the C- and N- terminal regions not included in the X-ray structure. (ii) To study effects of anionic phospholipids on the structure of the C-terminal region. (iii) To study the effects of phospholipid structure on ion permeation through KcsA, including effects of anionic lipids, bilayer thickness, and bilayer phase. (iv) To measure relative lipid binding constants for KcsA as a function of lipid structure, to relate to effects of phospholipids on ion permeation.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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