Award details

Application of chemical shifts to characterise structural changes in proteins

Reference	B11849
Principal Investigator / Supervisor	Professor Michael Williamson
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	121,216
Status	Completed
Type	Research Grant
Start date	14/03/2000
End date	07/09/2003
Duration	42 months

Abstract

The aim of the project is to use changes in 1H or 13C chemical shifts in proteins, with pressure, temperature or ligand binding, to characterise changes in their structure. The rationale for this is that it is much more accurate to calculate changes in shifts from changes in a known structure that it is to calculate the shifts themselves. The method will be cross- validated and compared to previous results. It will be applied to BPT1 and lysozyme in the first instance and then to other biologically interesting proteins. The programs and protocols developed will be made available via the Web.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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