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Isolation of 1-deoxyxylulose phosphatereducto-isomerase from plants
Reference
B11812
Principal Investigator / Supervisor
Professor David O'Hagan
Co-Investigators /
Co-Supervisors
Institution
University of St Andrews
Department
Biology
Funding type
Research
Value (£)
145,939
Status
Completed
Type
Research Grant
Start date
10/01/2000
End date
15/10/2003
Duration
45 months
Abstract
A collaborative research programme is proposed to isolate deoxyxylulose phosphaterducto- isomerase from plants for the first time. The enzyme has recently been isolated from a bacterium (E. coli) and this represents the first enzyme of the non-mevalonate pathway to be isolated. The programme will extend this now to a plant system. This enzyme is the first committed enzyme to the terpene secondary metabolites in plants. Our objective is to obtain the plant enzyme from Arabidopsis and then study mechanistic details, with a view to designing inhibitors of the enzyme. It is anticipated that such inhibitors could serve as herbicides (and also antibiotics). The programme will also study the upregulation of this enzyme after elicitation of plant systems to assess if this is the enzyme controlling flux to secondary metabolism.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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