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Development of chiral lanthanide metallointercalators as luminescent and spectroscopic probes for nucleic acids
Reference
B11761
Principal Investigator / Supervisor
Professor David Parker
Co-Investigators /
Co-Supervisors
Institution
Durham University
Department
Chemistry
Funding type
Research
Value (£)
254,385
Status
Completed
Type
Research Grant
Start date
01/11/1999
End date
01/11/2002
Duration
36 months
Abstract
The interaction of delta and lambda cationic lanthanide complexes with oligonucleotides and DNA will be studied by circular dichroism, luminescence, proton and phosphorus NMR and crystallography. Controlled variation of the structure of the complex will be correlated with binding studies to nucleic acids of defined conformation and sequence. Functional probes will be sought (e.g. terbium complexes as singlet oxygen producers; diaquo complexes to promote phosphate hydrolysis) in addition to structural probes for which site (CG vs AT) and enantioselectivity (delta vs lambda) in intercalative binding will be defined.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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