Award details

Structure Function and engineering of polyketide synthases

Reference	B11754
Principal Investigator / Supervisor	Professor Peter Leadlay
Co-Investigators / Co-Supervisors	Dr Jesus Cortes-Bargallo, Professor James Staunton
Institution	University of Cambridge
Department	Biochemistry
Funding type	Research
Value (£)	1,268,726
Status	Completed
Type	Research Grant
Start date	01/11/1999
End date	01/11/2004
Duration	60 months

Abstract

This project aims to define the enzymology of antibiotic-producing molecular polyketide synthases (PKSs): first, we aim to determine the structure of the modular PKSs; their modular nature means that it is possible to define smaller structural units whose X-ray crystal structure would reveal much about the architecture of these enzymes; secondly, we aim to establish the roles of individual domains in accomplishing the specificity and stereospecificity of polyketide chain extension; thirdly, we aim to show how this knowledge can be harnessed to produce novel polyketides; finally, we aim to exploit the (newly-cloned and sequenced) genes for a typical polyether ionophore to define the entire mechanistic pathway to this class of polyketides.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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