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Structural resolution modelling and simulation of the B-amyloid peptide in membranes

Reference	B11683
Principal Investigator / Supervisor	Professor Anthony Watts
Co-Investigators / Co-Supervisors	Dr Gerhard Grobner, Professor Mark Sansom
Institution	University of Oxford
Department	Biochemistry
Funding type	Research
Value (£)	192,068
Status	Completed
Type	Research Grant
Start date	01/05/1999
End date	01/08/2003
Duration	51 months

Abstract

We aim to use novel solid state NMR methods to resolve structural details at crystallographic (0.3 angstrom) resolution for membrane-embedded betaroteinamyloid peptide (1-40), and use these constraints to produce a precise molecular model for this medically relevant membrane peptide. This molecular model will be refined by MD simulations in a fully hydrated phospholipid bilayer to analyse the energetics and dynamics of peptide/bilayer/water interactions.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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