BBSRC Portfolio Analyser
Award details
Inter- and Intramolecular interactions mediated by TB domains
Reference
B11674
Principal Investigator / Supervisor
Dr Anna K Downing
Co-Investigators /
Co-Supervisors
Professor Penny Handford
Institution
University of Oxford
Department
Oxford Centre for Molecular Sciences
Funding type
Research
Value (£)
97,038
Status
Completed
Type
Research Grant
Start date
08/11/1999
End date
08/11/2001
Duration
24 months
Abstract
The TB module is found principally in proteins localised to extracellular matrix fibrils including human fibrillin-1 and LTBP-1. The identification of 16 missense mutations in fibrillin-1 TB domains which are associated with the Marfan syndrome underscores the importance of this domain. Functional studies have directly implicated a TB domain (TB3) in the association of LTBP-1 with LAP, part of the latent TGF-betal complex. Here we propose to study the structural and functional properties of a wild-type and mutant TB-cbEGF domain pair from fibrillin-1 and TB3 from LTBP-1 using NMR and coimmunoprecipitation of TB3-LAP complexes. This research will identify the roles of TB domains within extracellular matrix fibrils.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search