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Structural studies of a geminate virus particle: implications for capsid assembly and function

Reference	B11521
Principal Investigator / Supervisor	Professor Nigel Dimmock
Co-Investigators / Co-Supervisors	Dr Mavis Agbandje-McKenna, Dr Margaret Boulton, Professor Robert Conlan, Professor J Davies
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	164,692
Status	Completed
Type	Research Grant
Start date	01/04/2000
End date	01/04/2003
Duration	36 months

Abstract

The work will entail detailed structural studies on maize streak geminivirus (MSV), to allow the structure to be related to the biological functions associated with the virion. The main emphasis will be to understand the assembly of the twinned quasi-isometric germinate particles which are unique to geminiviruses. This will be achieved by using a variety of biophysical techniques including: multi-sequence alignments and structural modelling, solution scattering, cryo-electron microscopy, and single crystal X-ray diffraction studies. The information obtained will then be used to correlate and map the known functional regions of the capsid protein sequence to the three dimensional structural information.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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