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Synthesis and evaluation of thiamin diphosphate analogues
Reference
B11483
Principal Investigator / Supervisor
Dr Finian Leeper
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
159,236
Status
Completed
Type
Research Grant
Start date
18/10/1999
End date
20/05/2003
Duration
43 months
Abstract
Thiamin diphosphate-dependent enzymes catalyse a number of important reactions in which C-C bonds adjacent to C=O are made and broken. Although crystal structures of several TDP-dependent enzymes are available, their exact mode of actin and conformation during the reaction is still a matter of speculation. This project aims to synthesise for the first time stable analogues of TDP-bound intermediates. These analogues should bind to and inhibit strongly the major TDP-dependent enzymes and this will be tested. Crystal structures of the analogues bound in the enzyme active sites will also be obtained through collaboration with crystallographers. These studies will lead to a much greater insight into how these enzymes work.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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