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Atomic force microscopy as a tool for molecular mapping of mucin function

Reference	B11249
Principal Investigator / Supervisor	Professor Mervyn Miles
Co-Investigators / Co-Supervisors	Dr Monica Berry, Dr Anthony Corfield, Dr Terence McMaster
Institution	University of Bristol
Department	Physics
Funding type	Research
Value (£)	259,565
Status	Completed
Type	Research Grant
Start date	01/12/1998
End date	01/01/2003
Duration	49 months

Abstract

Specialised mucin populations have been implicated in specific functions, additional to those in the bulk mucous gel. The same mucin gene product, the same peptide backbone, can have different lengths and different glycosylation depending on origin and physiological status. The pattern of glycosylation, distribution of hydrophobic and hydrophilic regions and the location of sialic acid groups are important factors in the interaction of mucins with other molecules, and with immune and non-self cells. Atomic force microscopy will be used to characterise glycosylation and its function, taking, as a model, human ocular mucins.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	BioImaging (BI) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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