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Structure and function of a new-type inorganic pyrophosphatase
Reference
B11016
Principal Investigator / Supervisor
Dr Scott Andrew White
Co-Investigators /
Co-Supervisors
Dr T Young
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
145,206
Status
Completed
Type
Research Grant
Start date
27/09/1999
End date
10/03/2003
Duration
42 months
Abstract
Inorganic pyrophosphatases are key metabolic enzymes that provide the thermodynamic driving force behind DNA, RNA and polypeptide synthesis. It is believed they are essential to the cell. Recently, several microbes have been discovered to have a very different pyrophosphatase from the well-studied enzyme. This raises fundamental questions about the evolution and necessity of pyrophosphatases but also opens up new avenues in the search for new antimicrobial agents. We propose to: 1) determine the crystal structure of this new-type inorganic pyrophosphatase; 2) probe its catalytic mechanism; 3) determine whether it is essential to the cell.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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