Award details

Surface active calixarenes and tuberculosis therapies

Reference	B10963
Principal Investigator / Supervisor	Professor Helen Hailes
Co-Investigators / Co-Supervisors	Dr Alison Hill
Institution	University College London
Department	Chemistry
Funding type	Research
Value (£)	163,531
Status	Completed
Type	Research Grant
Start date	16/04/1999
End date	01/10/2002
Duration	42 months

Abstract

Tuberculosis (TB) results in approximately 3 million deaths each year, and the failure of the BCG vaccine to afford significant protection, the problems of multiple drug resistance, and the deadly combination of infection with M. tuberculosis and the human immuno-deficiency virus (HIV) have all served to stimulate a renewed drive to understand and tame this ancient disease. There is a particular interest in developing novel intervention strategies which act through the hosts defense mechanisms and hence reduce the risks of selecting drug resistant mutants. We plan to carry out structure/function analysis on a group of compounds, called calixarenes, with known antituberculous activity. We will synthesise novel surface active calixarenes, and the key structural features required for optimal biological activity will be identified in collaboration with Dr J Colston at NIMR. In addition we will synthesise the compounds to contain appropriate fluorescent labels; these labelled compounds will be used to study the intra-cellular location of the compounds with a view to understanding the biological basis of their activity.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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