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Modelling protein-protein interactions using 6D fourier correlation techniques
Reference
B10454
Principal Investigator / Supervisor
Professor Graham Kemp
Co-Investigators /
Co-Supervisors
Professor John Fothergill
Institution
University of Aberdeen
Department
Computing Science
Funding type
Research
Value (£)
96,168
Status
Completed
Type
Research Grant
Start date
23/11/1998
End date
23/11/2000
Duration
24 months
Abstract
The biological function of many proteins depends upon their ability to 'dock' with another protein of complementary shape and character. Although much is known about the binding of small ligands to proteins, protein-protein interaction is as yet poorly understood for many systems. the wealth of protein 3-dimensional structure information could be more fully exploited if it were possible to describe complementarity in computational terms. The aim of this project is to develop our method of modelling protein interactions using a novel 6-dimensional Fourier correlation technique. We plan to generate a rational structure-based methodology to facilitate 'docking' and to improve the design of protein-protein interfaces.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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