Award details

Structural studies on the novel E. coli haemolysin HIyE and associated transcriptional regulators and export proteins

Reference	B10338
Principal Investigator / Supervisor	Professor Peter Artymiuk
Co-Investigators / Co-Supervisors	Professor J Green
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	83,963
Status	Completed
Type	Research Grant
Start date	01/05/1999
End date	01/05/2001
Duration	24 months

Abstract

Many pathogens produce proteins, haemolysins, that have the ability to lyse erythrocytes and other host cells. Recently, a novel, chromosomally-encoded haemolysin, designed HlyE, has been identified in E. coli. Diffraction quality crystals of HlyE have been obtained and this proposal aims to determine its three dimensional structure. This work will give valuable insights into the presently unknown mode of action of HlyE. In addition crystallisation trials will be carried out on FNR transcriptional regulator of HlyE, and on proteins of the HlyE export system.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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