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Lead-protein interactions in the lead resistance regulator of Alcaligenes eutrophus
Reference
B10333
Principal Investigator / Supervisor
Professor Nigel Brown
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
116,126
Status
Completed
Type
Research Grant
Start date
01/02/1999
End date
01/02/2001
Duration
24 months
Abstract
A new lead resistance determinant (pbr) has been identified in the bacterium Alcaligenes eutrophus which encodes a metal export protein under the control of the lead-responsive regulatory protein, PbrR. PbrR responds in vivo to Pb but not to Hg or Zn, and is the first protein described for which the biological function is specifically to bind Pb. We propose to test whether this protein constitutes a Pb- specific hypersensitive biological switch and to investigate the mechanism of discriminatory recognition of Pb.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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