BBSRC Portfolio Analyser
Award details
Dehydroquinate synthase: exploitation of an active site that catalyses multistep chemical conversions for antimicrobial development
Reference
B10327
Principal Investigator / Supervisor
Dr Katherine Brown
Co-Investigators /
Co-Supervisors
Professor Alastair Hawkins
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
302,789
Status
Completed
Type
Research Grant
Start date
01/12/1998
End date
14/06/2002
Duration
42 months
Abstract
Catalysis and inhibition of dehydroquinate synthase (DHQS), an enzyme identified as a target for antimicrobial development, will be studied using a multi-disciplinary approach. The research programme aims to take advantage of our recent determination of a high resolution crystal structure for DHQS and existing high-level expression systems for recombinant forms of this enzyme from fungal and bacterial sources. Site-directed mutagenesis, X-ray crystallography and enzymological techniques will be used to develop a better understanding of the complex multi-step mechanism of DHQS. In addition, as part of an ongoing collaboration with a synthetic organic chemistry group, information from these studies will be used towards the rational design of new compounds with potential therapeutic value.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search