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New methods of solving protein structures
Reference
B10319
Principal Investigator / Supervisor
Professor C Gilmore
Co-Investigators /
Co-Supervisors
Professor Neil William Isaacs
,
Dr Adrian Lapthorn
Institution
University of Glasgow
Department
School of Chemistry
Funding type
Research
Value (£)
121,186
Status
Completed
Type
Research Grant
Start date
01/07/1999
End date
01/07/2002
Duration
36 months
Abstract
We intend to establish new procedures for solving difficult protein crystal structures using the maximum entropy-likelihood formalism. The methods will be applied to problems that are currently intractable: low resolution ab initio or near ab initio phasing when the crystals diffract to 4 angstroms or less, the determination of heavy atom co-ordinates for the MIR case where there is a serious lack of isomorphism, and MAD experiments with a very large number of Se atoms. In addition the methodology described can greatly assist with problems concerning the definition of protein envelopes, the resolution of MIR/SIR phase ambiguities, the determination of non-crystallographic symmetry parameters, phase refinement, and generation of the final electron density map. The methods will be incorporated into the standard CCP4 suite of computer programs.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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