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Analysis of the tertiary structure of the Hepatitis C IRES and its recognition by small molecule ligands
Reference
B10157
Principal Investigator / Supervisor
Dr Johanna Avis
Co-Investigators /
Co-Supervisors
Dr David J. Berrisford
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
179,867
Status
Completed
Type
Research Grant
Start date
12/10/1998
End date
12/10/2001
Duration
36 months
Abstract
The hepatitis C virus establishes persistent infection in humans, causing chronic liver disease and carcinoma. The most conserved region of the HCV genome is the 5'NTR required for translational initiation (the IRES). As part of a programme to investigate the function of the IRES and the potential of this region for drug targeting, this proposal aims to obtain tertiary structure information (X-ray) for this region and to initiate a search for lead compounds that bind the RNA specifically. There is precedence for both glycosides and peptides showing structure-selective RNA recognition. Both types of compound will be screened for IRES binding, in vitro and in vivo. A ligand may also stabilise the conformation of an IRES-derived RNA and promote crystallisation. The aims are ambitious and competitive but justified given the combined expertise and resources available.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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