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Resin screening and combinatorial fishing - a method of ligand self selection
Reference
B09914
Principal Investigator / Supervisor
Professor Mark Bradley
Co-Investigators /
Co-Supervisors
Institution
University of Southampton
Department
Sch of Chemistry
Funding type
Research
Value (£)
149,884
Status
Completed
Type
Research Grant
Start date
11/11/1998
End date
11/01/2002
Duration
38 months
Abstract
A method of unrivalled power in terms of compound number and ease of analysis will be developed for the combinatorial area. The aim is to enhance the numbers of compounds that can be screened in a library by several orders of magnitude but at the same time actually reduce the numbers of compounds that need to be synthesised. The modus operandi will be the dynamic generation of diversity and of enzyme self- selection strategy using a combination of solid and solution phase libraries and will use a 'resin capture strategy'. The process will enable multiple site binding and cooperativity to be investigated and exploited.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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