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Biosynthesis of collagen VI: chain recognition and oligomerisation
Reference
B09887
Principal Investigator / Supervisor
Professor Cay Kielty
Co-Investigators /
Co-Supervisors
Dr Charles Shuttleworth
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
169,512
Status
Completed
Type
Research Grant
Start date
01/02/1999
End date
01/04/2002
Duration
38 months
Abstract
Collagen VI is an essential structural connective tissue macromolecule which has a short triple-helix, multiple A-domains, and a unique biphasic intracellular and extracellular assembly. A-domains in many other proteins mediate cell-cell and cell- matrix adhesion functions that underlie crucial physiological processes such as morphogenesis, cell migration and haemostasis. This proposal aims to determine the molecular basis of collagen VI oligomerisation and the role of its A-domains in this hierarchical assembly. The study will define novel functions of A-domains as regulators of oligomerisation, provide insights into the molecular principles used by cells to produce multisubunit glycoproteins, and offer the potential to design novel collagens for tissue engineering and therapeutic uses.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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