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Chemical triple mutant boxes for the quantifying cooperativity in intermolecular interactions

Reference	B09842
Principal Investigator / Supervisor	Professor Christopher Hunter
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Chemistry
Funding type	Research
Value (£)	201,967
Status	Completed
Type	Research Grant
Start date	15/03/1999
End date	15/09/2002
Duration	42 months

Abstract

We propose to use synthetic H-bonded zipper complexes to make quantitative measurements of the magnitudes of co-operative effects in systems which are held together by multiple weak intermolecular interactions. The approach is a development of the double mutant cycles we have successfully used to quantify aromatic interactions. Two double mutant cycles constructed to measure the same functional group interaction will be combined into a triple mutant box which quantifies the thermodynamic sensitivity of the interaction to the context it finds itself in. A range of different functional group interactions and zippers will be examined, and so the experiments will establish how significant enthalpic co-operativity is in determining the properties of recognition systems. There are obvious implications for understanding molecular behaviour in chemistry and biology.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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