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Structural biology of ModE a molybdate-dependent transcriptional regulator
Reference
B09838
Principal Investigator / Supervisor
Professor William Hunter
Co-Investigators /
Co-Supervisors
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
137,118
Status
Completed
Type
Research Grant
Start date
01/08/1998
End date
01/12/2002
Duration
52 months
Abstract
Molybdenum is an essential element and the control of Mo uptake, the signalling mechanism, the regulation of gene expression and hence metabolism is carried out by a molybdate dependent transcriptional regulator called ModE. This protein can be classified as a member of the LysR family of transcriptional regulators. Crystals of E. coli ModE have been obtained that are suitable for a crystallographic analysis. Support is requested to allow for the characterisation of distinct conformational states of ModE and to attempt co-crystallisation of ModE to the DNA sequence to which it binds. The results could be the first complete picture of a member of this family of transcriptional regulators (repressor and activating stages) and an understanding of the structural biology implicated in the regulation of Mo metabolism.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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