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Structural studies of natural killer enhancing factor-B: a novel human antioxidant enzyme

Reference	B09807
Principal Investigator / Supervisor	Professor Jennifer Littlechild
Co-Investigators / Co-Supervisors
Institution	University of Exeter
Department	Biosciences
Funding type	Research
Value (£)	182,228
Status	Completed
Type	Research Grant
Start date	15/04/1998
End date	15/04/2001
Duration	36 months

Abstract

The primary aim of this project is to determine the three-dimensional atomic structure of human natural killer enhancing factor-B (NKEF-B) by X-ray crystallography. NKEF-B is a member of an emerging family of peroxidases, the peroxiredoxins, which influence the differentiation, proliferation and survival of a range of cell types. Peroxiredoxins are involved in regulating the levels of reactive oxygen species (ROS) within tissues. The damaging effects of ROS are implicated in ageing, cancer and heart disease, although ROS also play constructive roles in redox signalling and fighting infection. We will analyse the peroxidase mechanism by characterising NKEF-B inhibitor complexes by kinetics and X-ray crystallography, and also by investigating the binding of thioredoxin to NKEF-B by surface plasmon resonance and X-ray crystallography.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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