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Structural studies of allotropic variants of minute virus of mice (MVM) a murine parvovirus

Reference	B09795
Principal Investigator / Supervisor	Professor Nigel Dimmock
Co-Investigators / Co-Supervisors	Professor Robert Conlan
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	93,998
Status	Completed
Type	Research Grant
Start date	01/11/1998
End date	30/06/2000
Duration	20 months

Abstract

The successful infection of a host cell by a virion involves a series of macromolecular interactions and for the ssDNA Parvoviridae this process is highly dependent on host cell functions. For a number of parvoviruses, including MVM, the capsid protein has been shown to play a crucial role in tissue tropism. Two allotropic variants of MVM, MVMp and MVMi, can serve as ideal models for defining tropism-specific interactions for the Parvoviridae as a result of their pronounced differences in tissue tropism and pathogenicity, despite their 97% identity at the nucleotide level. Our main objectives are to (1) elucidate the nature and extent of protein-protein interactions on the parvoviral capsid surface required for permissive host infection (and pathogenesis) and (2) identify the site on the capsid surface used for receptor recognition, with the MVM variants as models, utilising the method of X-ray crystallography.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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