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Studies of Homocitrate synthase and other lysine pathway enzymes
Reference
B09743
Principal Investigator / Supervisor
Professor D Young
Co-Investigators /
Co-Supervisors
Institution
University of Sussex
Department
Chemistry
Funding type
Research
Value (£)
152,315
Status
Completed
Type
Research Grant
Start date
12/07/1999
End date
01/10/2002
Duration
39 months
Abstract
Homocitrate synthase and three other enzymes on the homocitrate pathway to lysine catalyse reactions which are completely analogous to reactions not only in the tricarboxylic acid cycle but also in the biosynthetic pathway to leucine. The enzymes in the homocitrate pathway are not well characterised unlike the enzymes in the latter pathways and comparisons between the analogous enzymes in the pathways will be of great interest. The enzymes will be over-expressed and purified and the stereochemistry and mechanism of action of the reactions catalysed by them will be determined. Homocitrate synthase is of particular interest because of its role in nitrogen fixation.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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