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Model systems for probing rare major- and minor- groove site metal ion binding
Reference
B09674
Principal Investigator / Supervisor
Professor Andrew Houlton
Co-Investigators /
Co-Supervisors
Institution
Newcastle University
Department
School of Chemistry
Funding type
Research
Value (£)
88,282
Status
Completed
Type
Research Grant
Start date
14/09/1998
End date
01/02/2001
Duration
29 months
Abstract
It is increasingly apparent that the rich structural diversity of nucleic acids ensures that metal ion binding is not restricted to those sites identified from simple alkylated nucleobase models. However, the value of model systems in gaining structural and spectroscopic information is without question. In this proposal a series of derivatised purine nucleobases is described which provide a means of assessing the interaction of metal ions with sites known, or implicated, as important in A-tracts, Holliday junctions, ribozymes and small molecules such as AMP. It is proposed to design model systems for investigating the interaction of these less reactive purine sites with heavy metals, essential d-block and Group I/II metals and to obtain detailed structural information for the resulting complexes using a combination of X-ray crystallography, NMR and MS.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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