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Structure - function analysis of the Sauromatum guttatum alternative oxidase using site-directed mutagenesis
Reference
B09673
Principal Investigator / Supervisor
Professor Anthony Moore
Co-Investigators /
Co-Supervisors
Institution
University of Sussex
Department
Sch of Life Sciences
Funding type
Research
Value (£)
52,100
Status
Completed
Type
Research Grant
Start date
01/06/1998
End date
01/06/1999
Duration
12 months
Abstract
The S. guttatum alternative oxidase has been targeted to the Schizosaccharomyces pombe mitochondria where it is expressed in an active form. The aim of this proposal is to probe the structure- function relationship of the plant alternative oxidase by mutating the two conserved cysteine residues proposed to be involved in post- translational regulation and also to investigate the nature of the ubiquinol- binding site. In order to determine which residues are important for activity we will analyse the respiratory characteristics of the altered protein using the yeast expression system.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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