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Combinatorial chemistry - practical single bead screening
Reference
B09512
Principal Investigator / Supervisor
Professor Mark Bradley
Co-Investigators /
Co-Supervisors
Institution
University of Southampton
Department
Sch of Chemistry
Funding type
Research
Value (£)
148,035
Status
Completed
Type
Research Grant
Start date
01/10/1998
End date
30/06/2002
Duration
45 months
Abstract
The synthesis of combinatorial libraries using the process of split and mix is an incredibly powerful technique in terms of the numbers of compounds that can be prepared (100,000-1,000,000). However, many complications have arisen with respect to screening these libraries and thus it is not a very widely-used technique. In addition, the cost of screening a million compounds alone can be prohibitive. This proposal is to develop a number of practical and highly efficient novel screening methodologies to screen libraries produced using split and mix techniques. At the forefront of these will be the development of zone diffusion assays for enzyme inhibitors using as a model the enzyme trypanothione reductase and polyamine based libraries. Dendrimerisation technology will allow sufficient quantities of library materials to be produced on single beads for screening.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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