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Molecular basis for resistance of bacteria towards vancomycin group antibiotics
Reference
B09289
Principal Investigator / Supervisor
Professor Dudley Williams
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
134,969
Status
Completed
Type
Research Grant
Start date
01/02/1998
End date
31/07/2001
Duration
42 months
Abstract
The objective of this research is to gain insight into the molecular basis for bacterial resistance towards the vancomycin group of glycopeptide antibiotics. Bacteria gain this resistance by the replacement of the terminal D-alanine residue of growing bacterial cell wall precursors with D-lactate. Following the synthesis of cell-wall analogues terminating in D-Ala-D-Lac, the dimerisation behaviour will be studied using high-field NMR techniques. Also, binding constants between ligands and antibiotics will be determined by UV spectrophotometry. The results should lead to a better understanding of the action of glycopeptides against vancomycin-resistant bacteria, and hence should help in the development of new antibiotics.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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