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Molecular mechanisms of integrin-ligand interactions: towards the design of synthetic inhibitors
Reference
B09059
Principal Investigator / Supervisor
Dr Peter Kilshaw
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
100,316
Status
Completed
Type
Research Grant
Start date
18/02/1998
End date
18/02/2000
Duration
24 months
Abstract
We plan to address three fundamental questions about the molecular mechanisms of ligand engagement by I-domain-containing integrins by studying the interaction between the mucosal T cell integrin alpha E beta 7 and its ligand E-cadherin. We shall determine: 1. Whether dimerisation of E-cadherin is required and, if so, why? 2. The identity of the site on E-cadherin recognised by the alpha E I-domain. 3. Whether interaction between alpha E beta 7 and E-cadherin exposes a ligand-induced binding site and whether it is possible to block this with a synthetic inhibitor. Our results will be relevant leukocyte integrins in general and provide basic information that is essential for the design of integrin antagonist drugs.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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