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Photocontrol of spatial and temporal solute release from liposomes sensitised with a photochromic phospholipid
Reference
B09058
Principal Investigator / Supervisor
Professor C Morgan
Co-Investigators /
Co-Supervisors
Professor Roger Hugh Bisby
Institution
University of Salford
Department
Biomedical Sciences Research Institute
Funding type
Research
Value (£)
106,770
Status
Completed
Type
Research Grant
Start date
01/01/1998
End date
01/04/2000
Duration
27 months
Abstract
We propose to investigate an alternative to conventional caging methodology based on entrapment of solutes within a liposome which is destabilised on illumination. Destabilisation is induced by photoisomerisation of a lipid bearing azobenzene substituents. Preliminary results have shown rapid solute release following a single laser pulse. The proposed work includes investigation of the kinetics and mechanism of solute release, light-induced permeability as a function of molecular size and effects of membrane composition and lipid phase on solute release.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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