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The elucidation and manipulation of the biosynthesis of aminoglycoside
Reference
B08573
Principal Investigator / Supervisor
Dr Jonathan Spencer
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
163,181
Status
Completed
Type
Research Grant
Start date
01/04/1998
End date
30/09/2001
Duration
42 months
Abstract
Aminoglycosides are a large class of clinically important antibiotics that include such significant compounds as gentamicin, neomycin and butirosin. It is proposed to investigate the mechanism of the key steps in the synthesis of butirosin. The biosynthetic genes for butirosin have recently been identified upstream of the resistance gene. This opens the way to manipulating the genes to produce novel aminoglycosides which may possess great clinical value.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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