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The structural basis of enzymatic xylan degradation: structure determination and application for organic synthesis
Reference
B08521
Principal Investigator / Supervisor
Professor Gideon Davies
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Chemistry
Funding type
Research
Value (£)
154,538
Status
Completed
Type
Research Grant
Start date
23/02/1998
End date
23/02/2001
Duration
36 months
Abstract
Understanding the specific recognition of diverse oligosaccharides by proteins and the mechanism of enzyme-mediated chemical modifications is a fundamental and challenging question for modern structural biology. The enzymatic degradation of xylans is at the heart of many industrial processes and of great environmental significance. Three enzymes working in harmony, play a key role: xylanse, acetyl xylan esterase and beta-xylosidase. We will determine the structure(s) of these enzymes in the presence of specifically synthesised oligosaccharide substrates and inhibitors. These studies will not only address fundamental questions about xylan degradation but also provide structural insight into the application of xylanolytic and related enzymes for carbohydrate synthesis.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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