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Structural investigations of eukaryotic RNA polymerase 'core' subunits
Reference
B08519
Principal Investigator / Supervisor
Professor Steve Matthews
Co-Investigators /
Co-Supervisors
Dr Robert Weinzierl
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
174,675
Status
Completed
Type
Research Grant
Start date
21/12/1998
End date
01/02/2002
Duration
37 months
Abstract
RNA polymerases are the only components of the transcriptional machinery that are directly involved in the synthesis of the end product, RNA. All eukaryotic RNA polymerases are very complex enzymes consisting of 12-15 distinct subunits. In the model system Saccharomyces cerevisiae all subunits of RNA polymerase II have been cloned and characterised by molecular genetic means. We propose to determine the high resolution 3D structures of key subunits by NMR spectroscopy. This structural information, in combination with functional studies, will enable models of RNA polymerase architecture to be proposed.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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