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The relationship between an enzyme activity and the control of transcription
Reference
B08493
Principal Investigator / Supervisor
Professor Lindsay Sawyer
Co-Investigators /
Co-Supervisors
Professor John Coggins
,
Professor Alastair Hawkins
Institution
University of Edinburgh
Department
Inst of Cell and Molecular Biology
Funding type
Research
Value (£)
85,384
Status
Completed
Type
Research Grant
Start date
01/12/1998
End date
16/10/2001
Duration
35 months
Abstract
Following on from the successful determination of the structure of the shikimate pathway enzyme 3-dehydroquinase, we wish to exploit the high resolution crystal structure of this type 1 enzyme from Salmonella typhi in order to (a) understand fully the reaction mechanism, (b) gain insight into how this enzyme recognises its substrate, (c) rationalise the large amount of protein chemical data that are now available for the enzyme and (d) if possible, to understand the chemical changes that have occurred during the recruitment of a dehydroquinase to the role of molecular sensor in the regulation of transcription.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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