BBSRC Portfolio Analyser
Award details
Folding and stability studies on the hormone- binding domain of the oestrogen receptor
Reference
B08490
Principal Investigator / Supervisor
Dr Sophie Jackson
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
144,672
Status
Completed
Type
Research Grant
Start date
21/09/1998
End date
21/09/2001
Duration
36 months
Abstract
Nuclear hormone receptors are a large family of proteins in which the folding and stability of the hormone-binding domain may play a critical mechanistic role. The focus of the proposed research is the oestrogen receptor, which is associated with many clinical disorders including breast cancer. A range of biophysical techniques will be used to characterise the folding and stability of this domain, including the effect of ligands, heat shock proteins, and clinically relevant mutations. These experiments will help to establish the precise mechanism of action of this important class of receptor, and the role of heat shock proteins and immunophilins in the cell.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search