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2'-C- functionalised olignucleotides: ribozymes antisense and directed evolution
Reference
B08483
Principal Investigator / Supervisor
Professor Richard Cosstick
Co-Investigators /
Co-Supervisors
Dr Ian ONeil
Institution
University of Liverpool
Department
Chemistry
Funding type
Research
Value (£)
141,347
Status
Completed
Type
Research Grant
Start date
01/01/1998
End date
04/09/2002
Duration
57 months
Abstract
Oligonucleotides containing 2'-functionalised nucleosides are expected to play an important role in the development of catalytic RNA (by extending the functional group diversity) and in antisense oligonucleotides (by providing resistance to nucleases). The programme will involve i) the synthesis of oligonucleotides containing the 2'-C- functionalised nucleosides. ii) A study of their ability to form stable duplexes, metal ion dependency of their association, their resistance to nucleases and a study of their metal ion-promoted hydrolysis. (iii) A systematic investigation of the ability of the triphosphates of these modified nucleosides to serve as substrates for DNA-dependent RNA polymerases.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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