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How do lipid forces modulate membrane protein folding?
Reference
B08427
Principal Investigator / Supervisor
Professor Paula Booth
Co-Investigators /
Co-Supervisors
Professor Richard Templer
Institution
University of Bristol
Department
Biochemistry
Funding type
Research
Value (£)
184,628
Status
Completed
Type
Research Grant
Start date
01/04/1998
End date
08/04/2001
Duration
36 months
Abstract
The lipids of biological membranes have a profound influence on their neighbouring membrane-bound receptors, signal transducers and ion channels. The aim of this project is to correlate the structural and biophysical properties of the membrane with the stability, activity and folding of the integral membrane protein bacteriorhodopsin. In particular we will address the role of the lateral pressure which the lipids impose on the embedded protein, using a model membrane whose composition we can vary to alter the lateral pressure
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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