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Transmembrane signalling

Reference	B08373
Principal Investigator / Supervisor	Professor Nicholas Williams
Co-Investigators / Co-Supervisors	Professor Christopher Hunter
Institution	University of Sheffield
Department	Chemistry
Funding type	Research
Value (£)	162,399
Status	Completed
Type	Research Grant
Start date	09/03/1998
End date	09/12/2001
Duration	45 months

Abstract

The aim is to develop a synthetic system which will transfer information across a lipid bilayer membrane. Similar to cellular signalling in biology, the approach will allow the preparation of compartmental structures such as vesicles in which the chemical properties of the contents can be modulated by the external environment. Initially, a variety of components will be screened to establish coupling of events between the outside and inside of vesicles, using fluorescence energy transfer to monitor dimerisation of transmembrane units. This will be extended to use the external recognition to activate internal catalysts to give amplification and chemical activation within the vesicle, where conditions can be tuned independently of environment.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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