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Molecular basis of protein carbohydrate recognition
Reference
B08307
Principal Investigator / Supervisor
Professor James Naismith
Co-Investigators /
Co-Supervisors
Institution
University of St Andrews
Department
Biology
Funding type
Research
Value (£)
164,329
Status
Completed
Type
Research Grant
Start date
26/10/1998
End date
25/06/2002
Duration
44 months
Abstract
Protein carbohydrate interactions are now regarded as central in biology. Development of therapeutics based on carbohydrates is hampered by a lack of understanding at the molecular level of the processes involved and their contribution to the overall free energy of binding. These processes are solvent exclusion, hydrogen bonding, water rearrangement and van der Waals interactions. Using a combination of micro-titration calorimetery, chemical synthesis, protein crystallography and modelling we will determine the contribution of each of these processes. Successful completion of this project will provide a rational basis for development of new carbohydrate based therapeutics.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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