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Exploiting physiological triggers for target transfection of cells by synthetic polymer-based vectors
Reference
B08268
Principal Investigator / Supervisor
Professor Leonard Seymour
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Cancer Sciences
Funding type
Research
Value (£)
146,498
Status
Completed
Type
Research Grant
Start date
01/04/1999
End date
01/04/2002
Duration
36 months
Abstract
This project will develop efficient and safe synthetic systems for targeted delivery of DNA in gene therapy. Self-assembling vectors will be prepared based on synthetic polymers and designed to be activated by endosomal and lysosomal triggers following internalisation into target cells. The vectors are polyelectrolyte particles stabilised by surface binding of multifunctional hydrophilic polymers, and the polymer coating will be designed for shedding in endosome or lysosome, liberating transfection-active DNA intracellularly. The project will focus on design of polymers and linkages capable of efficient vector stabilisation, together with rapid intracellular cleavage and efficient release of DNA.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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