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Application of combinatorial chemistry to the development of telomerase inhibitors
Reference
B08044
Principal Investigator / Supervisor
Professor Sir Shankar Balasubramanian
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
171,579
Status
Completed
Type
Research Grant
Start date
04/08/1997
End date
04/02/2001
Duration
42 months
Abstract
The proposal aims to develop bis-specific inhibitors that are highly selective for the enzyme telomerase. The inhibitors will be used as mechanistic probes and potential anticancer lead compounds. A combinatorial synthetic approach will be developed to generate peptide library derivatives of an antisense DNA or PNA oligomer targeted at the telomerase active site. Several assay possibilities will be explored to develop a high throughput screen suitable for selecting inhibitors of telomerase from the library.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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