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Structural and functional studies of DNA G:T mismatch very-short-patch-repair enzymes
Reference
B08022
Principal Investigator / Supervisor
Professor Bernard Connolly
Co-Investigators /
Co-Supervisors
Professor Laurence Pearl
,
Dr Renos Savva
Institution
Newcastle University
Department
School of Cell and Molecular Biosciences
Funding type
Research
Value (£)
298,009
Status
Completed
Type
Research Grant
Start date
01/10/1997
End date
31/03/2001
Duration
42 months
Abstract
Very-short-patch-repair enzymes are small endonucleases with the unique ability to recognise and cleave a pro-mutagenic G:T mismatch base-pair within the context of a specific DNA sequence. In order to understand how these enzymes achieve their simultaneous recognition of a sequence and a lesion, we propose a multidisciplinary project involving detailed biochemical, enzymological and mutagenesis studies of the specificity and mechanism of action of these enzymes, in combination with structural studies of the enzymes and trapped complexes with DNA substrates.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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