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The structural basis of FMDV-receptor recognition
Reference
B08019
Principal Investigator / Supervisor
Professor David Stuart
Co-Investigators /
Co-Supervisors
Dr Andrew King
Institution
University of Oxford
Department
Wellcome Trust Centre for Human Genetics
Funding type
Research
Value (£)
345,027
Status
Completed
Type
Research Grant
Start date
01/07/1997
End date
30/06/2001
Duration
48 months
Abstract
Foot-and-mouth disease virus (FMDV), an economically important and highly infectious picornavirus, enters cells via a two step mechanism. The process has parallels with many cell adhesion phenomena. There is initial contact with an abundant species (in this case heparan sulphate) followed by attachment to a member of the integrin family of cell surface proteins. We propose to investigate the structural basis of both of these interactions. This interdisciplinary project will make use of the unique range of reagents available to us, namely all of the structural components of the process, to build upon preliminary work which has shown the feasibility of visualising cognate virus-receptor complexes. The aim is to elucidate the molecular interactions at each step of cell attachment.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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