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The investigation of the conformational interconversion pathway of prion proteins using computer simulation
Reference
B08012
Principal Investigator / Supervisor
Professor Jonathan Essex
Co-Investigators /
Co-Supervisors
Institution
University of Southampton
Department
Sch of Chemistry
Funding type
Research
Value (£)
91,216
Status
Completed
Type
Research Grant
Start date
01/10/1997
End date
01/10/1999
Duration
24 months
Abstract
Prion diseases are neurodegenerative disorders that affect both man and other mammals, and include BSE and CJD. Prion illnesses are believed to involve the conformational interconversion of the native prion isoform PrPC to PrPSc. This ultimately results in neuronal cell death. In this proposal the application of molecular dynamics simulations to this problem is described. Simulations of wild type and mutant PrP (121-231) will be performed based on the recent NMR structure. The low frequency vibrations of the protein will be identified, and those involved in the conformational interconversion pathway will be stimulated to drive the conformational transition. Finally, specific ligands will be designed capable of stabilising PrPC.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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