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Structure/function relations in `so-called' prismane proteins

Reference	B08005
Principal Investigator / Supervisor	Professor Christopher Garner
Co-Investigators / Co-Supervisors	Professor Frank Mabbs
Institution	University of Nottingham
Department	Sch of Chemistry
Funding type	Research
Value (£)	133,861
Status	Completed
Type	Research Grant
Start date	08/02/1998
End date	08/06/2001
Duration	40 months

Abstract

A novel class of iron-sulphur proteins were designated prismanes, from their previously unrecognised spectroscopic properties, following the suggestion that they contained an [Fe6S6] core. Our current crystallographic work has unambiguously shown that the metal sites in one of these proteins comprises one [Fe4S4] and one dimeric ([Fe2S2] or [Fe20]?) centre. The understanding of the novel properties arising from the cooperation of two known iron cluster types is the basis of this application. We seek to address the structure/function relationships in prismane proteins, using the framework of known molecular structure, through a comb-prismane proteins, using the framework of known molecular structure, through a combination of protein crystallography, spectroscopy (XAS,EPR,ENDOR) and other biophysical measurements.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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