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Award details
Facilities for protein crystallography at Bristol
Reference
B07861
Principal Investigator / Supervisor
Professor R Brady
Co-Investigators /
Co-Supervisors
Dr Hilary Muirhead
Institution
University of Bristol
Department
Biochemistry
Funding type
Research
Value (£)
101,604
Status
Completed
Type
Research Grant
Start date
20/06/1997
End date
01/10/2000
Duration
40 months
Abstract
In this application we seek funding for an X-ray generator, operating costs and a postdoctoral assistant to underpin a varied programme of crystallographic-based structural biology projects at Bristol. These include projects addressing the mechanisms by which proteins bind, discriminate and cleave DNA bases (EcoRV, HIV integrase and the papillomavirus transcription factor E2), structured-based drug design (Plasmodium falciparum lactate dehydrogenase and HIV integrase), analyses of protein folding and engineering (antibodies, CD2, LDH and human prion proteins) and probing the basis of allostery in pyruvate kinase. These and other crystallographic projects form part of an integrated approach to biomolecular recognition at Bristol.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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