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Synthesis of mechanism-based inhibitors and probes for inositol monophosphatase
Reference
B07860
Principal Investigator / Supervisor
Professor David Gani
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
School of Chemistry
Funding type
Research
Value (£)
91,325
Status
Completed
Type
Research Grant
Start date
02/06/1997
End date
02/08/1999
Duration
26 months
Abstract
The mechanism and structure of inositol monophosphatase, the putative target for lithium therapy, have been determined recently in our laboratory. A new range of mechanism-based inhibitors for inositol monophosphatase will be synthesised by elaboration of O6-(2'- hydroxyethyl)-cyclohexane-1,2,4,6-tetraol phosphates and cyclic phosphates using new methodologies and incorporating solid-phase techniques starting from (-)-quinic acid. The compounds will be tested and the results will be used to test our understanding and to design and prepare highly specific compounds of potential medicinal value.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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