Award details

Leeds centre for molecular recognition in biological science

Reference	B07437
Principal Investigator / Supervisor	Professor Simon Phillips
Co-Investigators / Co-Supervisors	Professor Peter Stockley
Institution	University of Leeds
Department	Inst of Molecular & Cellular Biology
Funding type	Research
Value (£)	59,595
Status	Completed
Type	Research Grant
Start date	01/10/1996
End date	31/07/1998
Duration	22 months

Abstract

This award is a top-up extension to B02854 and B03070.Abstract for B02854: We shall maintain our interdisciplinary approach to the study of the structural basis of the functioning and control of biological processes at the molecular level. We shall continue to use our established physical techniques of X-ray crystallography, NMR spectroscopy, and electron microscopy, and are applying for enhancement of instrumentation for these methods. We wish to introduce the important new method of surface plasmon resonance spectroscopy to study molecular interactions in solution in real time. Development of our molecular biological work, increasingly integrated with the physical methods, requires provision of a DNA sequencing facility. We shall expand our programme of research on protein/protein, protein/nucleic acid and protein/ligand interactions, including the important roles of carbohydrates. Notable developments in our portfolio of projects include an increasing emphasis on plant systems and expansion of work on membrane transport processes.Abstract for B03070: We shall maintain our interdisciplinary approach to the study of the structural basis of the functioning and control of biological processes at the molecular level. We shall use our established techniques of X-ray crystallography, NMR spectroscopy, electron microscopy, protein chemistry, computing and molecular biology to study protein/protein, protein/nucleic acid and protein/ligand interactions. Important current developments are the use of surface plasmon resonance spectroscopy and expansion of work on membrane transport processes.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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